Researchers clock DNA's recovery time after chemotherapy

The lab of Aziz Sancar, MD, PhD, published a paper in the Journal of Biological Chemistry that could inform the creation of 'chronochemotherapies' - strategies using chemo to treat cancer patients at particular times of day to maximize therapeutic benefit and minimize side effects.


Li, postdoctoral fellow in Sancar lab, receives 2018 EMGS and PARE Awards

Wentao Li, PhD, a postdoctoral fellow in the lab of Dr. Aziz Sancar, has received the 2018 Environmental Mutagenesis & Genomics Society (EMGS) New Investigator Travel Award & 2018 Postdoctoral Award for Research Excellence (PARE) from UNC Office of Postdoctoral Affairs.

Vaughn awarded Scott Neil Schwirck Fellowship

Courtney Vaughn, MD-PhD student in the lab of Aziz Sancar, MD, PhD, was awarded the Scott Neil Schwirck fellowship for her work studying the role of DNA damage repair and circadian rhythm in tumor response to platinum-based chemotherapy.

Could Reading our Circadian Clocks According to DNA Repair Optimize Chemotherapy?

For the first time, UNC School of Medicine scientists led by Nobel laureate Aziz Sancar analyzed whole-genome DNA repair in an animal over 24 hours to find which genes were repaired, where exactly, and when, laying the groundwork for a more precise use of anti-cancer drugs.

How Does Plant DNA Avoid the Ravages of UV Radiation?

The lab of UNC Nobel laureate Aziz Sancar, MD, PhD, reveals first-ever repair map of an entire multicellular organism to illuminate some interesting inner workings of the plant kingdom’s DNA highly efficient repair system.


Where Cigarette Smoking’s Damage is Done ... Down to Your DNA

A new technique from UNC School of Medicine scientists led by Nobel Prize winner Aziz Sancar reveals the genome-wide DNA damage that a major carcinogen causes.

How Life Survives: UNC researchers confirm basic mechanism of DNA repair

Findings come from an advanced DNA sequencing application developed by the lab of University of North Carolina Nobel Laureate Aziz Sancar.


Sancar delivers Norma Berryhill Distinguished Lecture

On Oct. 20, 2016, Aziz Sancar, MD, PhD, 2015 Nobel Laureate, Sarah Graham Kenan Professor of Biochemistry and Biophysics, delivered the annual Norma Berryhill Distinguished Lecture.

Sancar and Kibbe elected to National Academy of Medicine

Nobel Prize Winner Aziz Sancar, MD, PhD and Melina Kibbe, MD join only twelve current and former UNC School of Medicine faculty members in the prestigious National Academy of Medicine.

Sancar to receive the NC Award, the state's highest honor

The state's highest civilian honor, the North Carolina Award, will be presented to six distinguished North Carolinians on Thursday, September 22. Congratulations to Drs. Aziz Sancar and Paul Modrich who are among the six honorees.

Aziz Sancar accepts 2016 O. Max Gardner Award

Dr. Aziz Sancar, Distinguished Professor of Biochemistry & Biophysics and 2015 Nobel Laureate in Chemistry earns the 2016 O. Max Gardner Award, the highest faculty honor awarded by the UNC Board of Govenors.

Carnegie Corporation tabs Aziz Sancar as “Great Immigrant” honoree

Each year on Independence Day, the organization publishes its list entitled “Great Immigrants: The Pride of America” to honor the accomplishments of notable immigrants. Dr. Aziz Sancar, 2015 Nobel Laureate in Chemistry is a 2016 Carnegie Corporation honoree.

UNC Nobel laureates Oliver Smithies and Aziz Sancar present medals to UNC

Sancar, the 2015 winner of the Nobel Prize in Chemistry, donated his prize money to a Chapel Hill foundation. Smithies donated his monetary award to four universities, including UNC.

Carolina's Nobel Laureates meet President Spellings

On March 23, 2016, Carolina's two Nobel laureates, Oliver Smithies, Distinguished Professor of Pathology and Aziz Sancar, Distinguished Professor of Biochemistry & Biophysics meet with new UNC system President Margaret Spellings.

Harriet Fulbright Institute announces the Prof. Aziz Sancar Girls in STEM Project

Seven hundred girls from seven cities in Turkey will engage in science, technology, engineering, and math education during a series of three-day conferences.

Sancar receives top honor from Triangle Business Journal

Congratulations to Dr. Aziz Sancar, Distinguished Professor of Biochemistry & Biophysics, who received the 2016 Lifetime Achievement Award from the Triangle Business Journal and is named as one of their Healthcare Heroes for the year.

Sancar and Modrich honored as "Heroes of the Game"

On January 15, during Teacher Appreciation night, Aziz Sancar of UNC and Paul Modrich of Duke were honored as "Heroes of the Game" for their shared 2015 Nobel prize in chemistry.


Aziz Sancar honored as Tar Heel of the Year

2015 Tar Heels of the Year are Aziz Sancar of the University of North Carolina and Paul Modrich of Duke University.

The Man Behind the Nobel Prize

In this video, learn more about Aziz Sancar, the Sarah Graham Kenan Professor of Biochemistry and Biophysics and Nobel Prize Laureate in Chemisty for 2015.

Aziz Sancar receives 2015 Nobel Prize in Chemistry

UNC researchers create DNA repair map of the entire human genome

The new experimental assay can help scientists find the precise locations of repair of DNA damage caused by UV radiation and common chemotherapies. The invention could lead to better cancer drugs or improvements in the potency of existing ones.


Sancar lab finds final pieces to the circadian clock puzzle

Sixteen years after scientists found the genes that control the circadian clock in all cells, the lab of UNC’s Aziz Sancar, MD, PhD, discovered the mechanisms responsible for keeping the clock in sync.

Sancar lab manuscript selected as "Paper of the Week" by JBC

The paper titled "Mechanism of Photosignaling by Drosophila Cryptochrome: Role of the Redox Status of the Flavin Chromophore" appears in the February 21, 2014 print edition of The Journal of Biological Chemistry.


Sancar lab featured on "In This Issue" of PNAS, published on November 15, 2011

Exposure to UV radiation triggers DNA lesions that can lead to skin cancer, the most common type of cancer in the United States. Previous studies in mice have shown that levels of a protein called XPA, involved in repairing UV-induced DNA lesions, waxes and wanes with the time of day. Shobhan Gaddameedhi et al. found that the protein's level and activity in mouse skin cells are at their lowest at 4 AM and their highest at 4PM.

Sancar lab featured on the cover of JBC published on July 22, 2011

On the JBC Cover: The circadian clock is the internal timekeeping molecular system that generates a daily rhythm in an organism's physiology and behavior.