The lab of Aziz Sancar, MD, PhD, published a paper in the Journal of Biological Chemistry that could inform the creation of 'chronochemotherapies' - strategies using chemo to treat cancer patients at particular times of day to maximize therapeutic benefit and minimize side effects.
Wentao Li, PhD, a postdoctoral fellow in the lab of Dr. Aziz Sancar, has received the 2018 Environmental Mutagenesis & Genomics Society (EMGS) New Investigator Travel Award & 2018 Postdoctoral Award for Research Excellence (PARE) from UNC Office of Postdoctoral Affairs.
Courtney Vaughn, MD-PhD student in the lab of Aziz Sancar, MD, PhD, was awarded the Scott Neil Schwirck fellowship for her work studying the role of DNA damage repair and circadian rhythm in tumor response to platinum-based chemotherapy.
For the first time, UNC School of Medicine scientists led by Nobel laureate Aziz Sancar analyzed whole-genome DNA repair in an animal over 24 hours to find which genes were repaired, where exactly, and when, laying the groundwork for a more precise use of anti-cancer drugs.
The lab of UNC Nobel laureate Aziz Sancar, MD, PhD, reveals first-ever repair map of an entire multicellular organism to illuminate some interesting inner workings of the plant kingdom’s DNA highly efficient repair system.
A new technique from UNC School of Medicine scientists led by Nobel Prize winner Aziz Sancar reveals the genome-wide DNA damage that a major carcinogen causes.
Findings come from an advanced DNA sequencing application developed by the lab of University of North Carolina Nobel Laureate Aziz Sancar.
On Oct. 20, 2016, Aziz Sancar, MD, PhD, 2015 Nobel Laureate, Sarah Graham Kenan Professor of Biochemistry and Biophysics, delivered the annual Norma Berryhill Distinguished Lecture.
Nobel Prize Winner Aziz Sancar, MD, PhD and Melina Kibbe, MD join only twelve current and former UNC School of Medicine faculty members in the prestigious National Academy of Medicine.
The state's highest civilian honor, the North Carolina Award, will be presented to six distinguished North Carolinians on Thursday, September 22. Congratulations to Drs. Aziz Sancar and Paul Modrich who are among the six honorees.
Dr. Aziz Sancar, Distinguished Professor of Biochemistry & Biophysics and 2015 Nobel Laureate in Chemistry earns the 2016 O. Max Gardner Award, the highest faculty honor awarded by the UNC Board of Govenors.
Each year on Independence Day, the organization publishes its list entitled “Great Immigrants: The Pride of America” to honor the accomplishments of notable immigrants. Dr. Aziz Sancar, 2015 Nobel Laureate in Chemistry is a 2016 Carnegie Corporation honoree.
Sancar, the 2015 winner of the Nobel Prize in Chemistry, donated his prize money to a Chapel Hill foundation. Smithies donated his monetary award to four universities, including UNC.
On March 23, 2016, Carolina's two Nobel laureates, Oliver Smithies, Distinguished Professor of Pathology and Aziz Sancar, Distinguished Professor of Biochemistry & Biophysics meet with new UNC system President Margaret Spellings.
Seven hundred girls from seven cities in Turkey will engage in science, technology, engineering, and math education during a series of three-day conferences.
Congratulations to Dr. Aziz Sancar, Distinguished Professor of Biochemistry & Biophysics, who received the 2016 Lifetime Achievement Award from the Triangle Business Journal and is named as one of their Healthcare Heroes for the year.
On January 15, during Teacher Appreciation night, Aziz Sancar of UNC and Paul Modrich of Duke were honored as "Heroes of the Game" for their shared 2015 Nobel prize in chemistry.
2015 Tar Heels of the Year are Aziz Sancar of the University of North Carolina and Paul Modrich of Duke University.
In this video, learn more about Aziz Sancar, the Sarah Graham Kenan Professor of Biochemistry and Biophysics and Nobel Prize Laureate in Chemisty for 2015.
The new experimental assay can help scientists find the precise locations of repair of DNA damage caused by UV radiation and common chemotherapies. The invention could lead to better cancer drugs or improvements in the potency of existing ones.
Sixteen years after scientists found the genes that control the circadian clock in all cells, the lab of UNC’s Aziz Sancar, MD, PhD, discovered the mechanisms responsible for keeping the clock in sync.
The paper titled "Mechanism of Photosignaling by Drosophila Cryptochrome: Role of the Redox Status of the Flavin Chromophore" appears in the February 21, 2014 print edition of The Journal of Biological Chemistry.
Exposure to UV radiation triggers DNA lesions that can lead to skin cancer, the most common type of cancer in the United States. Previous studies in mice have shown that levels of a protein called XPA, involved in repairing UV-induced DNA lesions, waxes and wanes with the time of day. Shobhan Gaddameedhi et al. found that the protein's level and activity in mouse skin cells are at their lowest at 4 AM and their highest at 4PM.
On the JBC Cover: The circadian clock is the internal timekeeping molecular system that generates a daily rhythm in an organism's physiology and behavior.